Pregnancy-Associated Plasma Protein-A

A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human FIBROBLASTS, ovarian FOLLICULAR FLUID, and GRANULOSA CELLS. The enzyme is a heterotetramer of about 500-kDa.

Also Known As:

PAPP-A; IGFBP-4 Metalloproteinase; IGFBP-4 Protease; IGFBP-4-Specific Proteinase; Insulin-Like Growth Factor-Dependent IGF Binding Protein-4 Protease; Insulin-Like-Growth Factor Binding Protein-4 Protease; PAPP-alpha; Pregnancy Associated alpha Plasma Protein; Pregnancy-Associated alpha-Plasma Protein; IGFBP 4 Metalloproteinase; IGFBP 4 Protease; Insulin Like Growth Factor Binding Protein 4 Protease; Insulin Like Growth Factor Dependent IGF Binding Protein 4 Protease; Metalloproteinase, IGFBP-4; PAPP alpha; Pregnancy Associated Plasma Protein A; Protease, IGFBP-4

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Hydrolases: 2206
    - Peptide Hydrolases: 24289
      - Metalloproteases: 8398
        Metalloendopeptidases: 70
        Pregnancy-Associated Plasma Protein-A: 1224
      - Endopeptidases: 643
        Metalloendopeptidases: 70
        Pregnancy-Associated Plasma Protein-A: 1224
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Pregnancy Proteins: 99
    - Pregnancy-Associated Plasma Protein-A: 1224

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Disease

Drug/Important Bio-Agent (IBA)